10 Best Proteolytic Enzymes – (Guide And Comparison)

Are you looking for the most reliable and efficient proteolytic enzymes in the market? If the answer to the question is yes, then you are in luck because your good luck has brought you to the best possible place. We are here to save your time and relieve you of the stress of going through a plethora of reviews.

It is quite a common phenomenon to be confused over which is the proteolytic enzymes to buy. This dilemma arises due to the existence of various types of proteolytic enzymess that are present in the market.  To reduce your conundrum, we have prepared a comprehensive guide of how you may pick the best proteolytic enzymess available in the market.

Our Recommended 10 Best proteolytic enzymes in 2022

Bestseller No. 1
Doctor's Best Proteolytic enzymes, Digestion, Muscle, Joint, Non-GMO, Gluten Free, Vegetarian, 90 Veggie Caps
  • Doctor's Best Proteolytic Enzymes is a potent formulation containing a broad spectrum of proteolytic enzymes (proteases).
  • Product Note: Exposure to heat or sunlight may lead to melting/damage of product. Hence customers are expected to be available during the product delivery
  • Proteolytic enzymes function in the body to digest and break down proteins into their amino acid components
  • Proteolytic Enzymes Provide Support for Muscle, Joint, and Overall Tissue Health
  • Proteolytic Enzymes will appear in clear encapsulation, with no enteric coating and the potency, safety and quality of this product will remain the same
Bestseller No. 2
Wonder Laboratories Proteolytic Enzymes | Bromelain Papain Pancreatin Trypsin 450 mg Total with Standardized Amylase, Lipase, and Protease, 300 Tablets
  • Nutritionally Supports Your Body's Natural Response to Inflammation, Immune Function, and Supports Digestive and Intestinal Health*
  • Contains Bromelain, Lipase, Trypsin, Papain, Pancreatin, Chymotrypsin, Protease, and Amylase
  • Bromelain and Proteolytic Enzymes to help support the breakdown of proteins in digestion, immune function, and other vital processes.*
  • Amylase Lipase Bromelain Digestive Enzymes Organic Sources to provide you with a well formulated digestive enzyme
  • MADE IN USA - Manufactured and packaged in the USA by a family owned and operated company since 1962.
Bestseller No. 3
Serrapeptase 240,000 SPU Max Potency (120 Vegan Capsules) Proteolytic Enzyme for Sinus, Respiratory and Joint Health (Manufactured and Tested in The USA) by Double Wood Supplements
  • Reduce Mucus Production: Multiple studies show Serrapeptase may help decrease the viscosity of mucus which may help nasal discharge
  • Supports Healthy Immune Response: Some research suggests Serrapeptase may help support a healthy immune response
  • Systemic Proteolytic Enzyme: Serrapeptase is classified as a proteolytic enzyme meaning it digests certain proteins
  • Max 240,000 SPU Dose and Two Month Supply: Each 2 capsule serving double of Double Wood's Serrapeptase contains 240,000 SPU and each bottle contains 60 servings
  • Manufactured and Tested in the USA, Non-GMO, Gluten Free, Vegetarian Safe: DoubleWood's Serrapeptase Capsules are Manufactured and Tested right here in the USA, are Non-GMO, Gluten Free, and safe for Vegetarians
Bestseller No. 4
Garden of Life Systemic Enzymes - FYI Restore for Muscle and Tissue Recovery for Women and Men, Vegan Enzyme Supplement, Bromelain, Protease, Papain, Vegan and Gluten Free, 60 Enteric Coated Capsules
  • MUSCLE & TISSUE RECOVERY: FYI Restore is the ultimate broad spectrum systemic enzyme formula; This high activity systemic enzymes formula works with the body's own processes to support normal tissue repair and recovery
  • MUSCLE SUPPLEMENT: This muscle repair supplement provides high levels of bromelain & papain to aid normal fibrin turnover and support healthy microcirculation in overused tissue; Systemic enzyme blend includes protease, nattokinase and serratiopeptidase
  • PROTEOLYTIC ACTIVITY: Contains a highly potent range of systemic enzymes, citrus and rutin bioflavonoids—plus alfalfa, algae and an ionic mineral blend with trace minerals, for healthy connective tissue integrity and turnover
  • ENTERIC-COATED VEGAN CAPSULES: Our muscle recovery supplement for men and women comes in capsules with algae based enteric coating to ensure the highly active systemic enzymes reach the small intestine for maximum effectiveness and targeted absorption
  • VEGAN SYSTEMIC ENZYME SUPPLEMENT: Our muscle and tissue recovery bromelain supplement is 100% Vegetarian and Vegan, Dairy Free, Gluten Free and Carbon Neutral
SaleBestseller No. 5
HEAL-N-SOOTHE Anti Inflammatory Supplement Proteolytic Enzyme - Natural Joint Supplement for Inflammation Joint Relief 90 Count for Men and Women
  • SUPPORTS JOINT HEALTH, COMFORT AND FLEXIBILITY: Each capsule of Heal-n-Soothe contains a powerful blend of Proteolytic Enzymes, Organic Turmeric Extract, Bromelain, Boswellia Extract, Papain, Rutin, Mojave Yucca Root, Devil's Claw, Citrus Bioflavonoids, Alpha Lipoic Acid and Ginger supplement. These natural ingredients work synergistically to tackle tough joint concerns as well as common everyday aches and pains.
  • SCIENTIFICALLY FORMULATED PROTEOLYTIC ENZYMES TO SUPPORT A HEALTHY IMMUNE SYSTEM: Heal-n-Soothe is formulated to be the strongest and highest potency proteolytic enzyme formulation available. Each dosage is clinically tested to help alleviate joint discomfort.
  • BETTER THAN ORDINARY TURMERIC CURCUMIN SUPPLEMENTS: Heal-n-Soothe does contain 60mg of turmeric, a widely recognized antioxidant to reduce free radicals in your body. But we didn't stop there. In addition to turmeric, Heal-n-Soothe contains 12 more natural ingredients, designed to deliver maximum natural joint support. That's why Heal-n-Soothe is superior to ordinary turmeric supplements.
  • ALL NATURAL, VEGETARIAN, NON-GMO, NO FILLERS, BINDERS OR PRESERVATIVES: This is a high-quality, all-natural, non-GMO, gluten-free formula. There are no reported side effects with this product. Our Heal-n-Soothe joint supplement is a wonderful choice for people who wish to improve joint health and mobility.
  • GET BACK TO LIVING LIFE TO THE FULLEST: Whether it's golfing, gardening, or even just performing everyday household chores, Heal-n-Soothe helps ease tender joints and get you back to your favorite hobbies. Just take the recommended dosage every day. Soon, you'll be back to living life on your terms.
SaleBestseller No. 6
Herbal Secrets Bromelain 500 Mg Tablets (Non-GMO)- Proteolytic Enzyme* Anti-Inflammatory Properties* Support Joint Health* Promotes Nutrient Absorption* (120 Count (Pack of 2))
  • SUPPORT FOR DIGESTION & MORE Bromelain Supports Healthy Digestion, Provides Anti-Inflammation and Aids In The Absorption Of Vital Nutrients.
  • OPTIMAL DOSE Each Of Our Bromelain Tablet Provide 500mg Bromelian Dosage. An Optimum Dosage to Reap Bromelian Benefits
  • ALL-NATURAL BROMELAIN Bromelian Digestive Enzymes Is Extracted From Pineapples. Herbal Secrets Bromelian Tables Contain Pure Bromelian With No Preservatives, Artificial Sweeteners, Colors Or Flavors.
  • PREMIUM QUALITY All Herbal Secrets products are manufactured in accordance with Good Manufacturing Practices (GMP), among the highest standards in the world. We do not compromise on quality, our products are free of Artificial Colors, Preservatives, or Flavors.
  • MADE IN USA All our products are proudly made in USA with Guaranteed Purity & Potency. We offer best quality products for the best value. All our products are Third Party Tested.
Bestseller No. 7
Proteolytic Enzymes, 90 Delayed Release Veggie Capsules, California Gold Nutrition
  • DELAYED RELEASE CAPSULES: This broad spectrum enzyme blend is protected within delayed release capsules, helping to deliver the enzymes directly to the small intestine for targeted efficiency.*
  • DELIVERS HEALTH BENEFITS*: Proteolytic enzymes are known for breaking down proteins and can help promote a healthy immune system, support anti-inflammatory functions, and help to break down mucus.*
  • DIGESTIVE BLEND: This supplement contains a fruit-derived digestive enzyme blend with bromelain and papain. Both of these enzymes are thought to help support digestion and potentially reduce inflammation.*
  • PANCREATIN ALTERNATIVE BLEND: This product features a non-animal based pancreatin alternative blend with protease, amylase, and lipase, all of which are thought to help support immune health.*
  • COMMITMENT TO QUALITY: California Gold Nutrition strives to use quality ingredients in all formulations. This product contains no GMOs and is suitable for vegetarians.
Bestseller No. 8
WellnessOne Proteolytic Enzymes Supplements w/ Nattokinase & Seapose - Pro-OneZyme Systemic Proteolytic Enzymes Support for Muscles, Joint & Digestion Systemic Enzymes Supplement - 90 Capsules
  • 𝗨𝗡𝗜𝗤𝗨𝗘𝗟𝗬 𝗙𝗢𝗥𝗠𝗨𝗟𝗔𝗧𝗘𝗗 - ProOneZyme is the only supplement that contains 6 of the best quality proteolytic enzymes in one convenient enzymes proteolytic vegan capsule. These ingredients include Bromelain, Nattokinase, Papain, Peptidase, Protease, Seaprose, Catalase and Rutin
  • 𝗔𝗟𝗟 𝗡𝗔𝗧𝗨𝗥𝗔𝗟𝗟𝗬 𝗠𝗔𝗗𝗘 - Proteolytic enzyme contains no wheat, yeast, soy or gluten. NO animal derivatives, sugars, artificial flavors, colors or fillers. Systemic and proteolytic enzymes are perfect for vegetarians and meat lovers alike!
  • 𝗣𝗘𝗥𝗙𝗢𝗥𝗠𝗔𝗡𝗖𝗘 𝗗𝗥𝗜𝗩𝗘𝗡 - Proteolytic Systemic Enzymes gives active enzymes the body can use. They can also work in part to help digest food & are a proteolytic boost for inflamed joints. When the body is happy, you feel younger and full of life.
  • 𝗣𝗢𝗪𝗘𝗥𝗙𝗨𝗟 𝗔𝗡𝗗 𝗣𝗥𝗢𝗩𝗘𝗡 - Nattokinase and Seaprose are gentle on the stomach. ProOneZyme proteolytic enzyme capsules are designed to withstand stomach acid and release inside the intestinal tract where it is absorbed and used in the body.
  • 𝟭𝟬𝟬% 𝗥𝗜𝗦𝗞 𝗙𝗥𝗘𝗘 𝗚𝗨𝗔𝗥𝗔𝗡𝗧𝗘𝗘! If for any reason you are not satisfied with ProOneZyme, simply return any unused portion for a full no hassle, 30-Day Money-Back Guarantee! Third Party Tested and manufactured in a GMP Facility.
Bestseller No. 9
Proteolytic Enzymes: Trypsin & Chymotrypsin by Amvilab, Proteolytic Enzymes Supplement, Supports Tissue Health, Reduces Edema & Inflammation caused by Tissue Injury, Fast Recovery - 60 capsules
  • REDUCES INFLAMMATION AND PAIN, SPEED UP HEALING: in our anti inflammatory supplement, Trypsin & Chymotrypsin, work on micro-wounds and clear debris, acting as a pro-healing supplement, countering inflammation and reducing edema in accidental injuries, surgical and orthopedic injuries, and burns.
  • IMPROVES JOINTS, MUSCLES, AND TISSUE HEALTH: AMVILAB SYSTEMIC PROTEOLYTIC ENZYMES contains a combination of Trypsin & Chymotrypsin to improve joint and muscle health by helping important metabolic pathways, improving tissue health, and making you feel strong.
  • BOOST IMMUNE SYSTEM HEALTH: backed by scientific evidence, systemic proteolytic enzymes boost the immune system by helping clear the debris and bad proteins that cause inflammation in the body.
  • IMPROVES CIRCULATION: systemic proteolytic enzymes for inflammation help to initiate tissue repair, remove dead cells, and reduce blockages in vessels, allowing healthy tissues to grow.
  • 100% REFUND POLICY IF NO RESULTS: if you don't get results from our systemic proteolytic enzymes for inflammation pain, we have a 100% refund policy.
Bestseller No. 10
AST Enzymes Excellacor – Proteolytic Systemic Enzymes Formula – with Enteric-Coated Serrapeptase - Total Body Support - 90 Vegetarian Capsules
  • ADVANCED SYSTEMIC ENZYME FORMULA: a potent blend of enteric-coated Serrapeptase, proteases and herbs that synergistically support the body’s natural response to inflammation and joint function; used for more than a decade by thousands of people as a daily dietary supplement.*
  • RANGE OF USE: Supports the body’s natural response to inflammation including fatigued muscles and joint function, healthy blood circulation, and healthy fibrin metabolism.*
  • ACHIEVE OPTIMAL HEALTH: Elimination of potential waste substances from the body is a crucial step in metabolic processes for optimal health. Excellacor improves the body’s ability to rid of these wastes and restore normal balance.*
  • QUALITY ASSURED: All products by AST Enzymes are manufactured in the USA, free of animal derivatives, dairy, yeast, fish or shellfish, peanuts, and tree nuts.

Best Recommendations and Buying Guide for your proteolytic enzymes

Before you venture out to purchase your preferred proteolytic enzymes, take into consideration some factors. These factors will ultimately help you decide which proteolytic enzymes is the right fit for your requirements.

Use the internet to do your research about all the available proteolytic enzymess in the market. This is helpful for both online and retail/ in-person purchases. If you are buying from an online marketplace, try to ascertain the most trustworthy online store. Usually, the online shops that have the highest following of masses are the best ones.

These shops not only provide reliable products but also give the buyers a lot of diversified products to choose from. Search for the different types of proteolytic enzymes available in the online store and find ones to choose from.

Read the reviews of people on the online pages to understand the detailed and nuanced pros and cons that entail this particular proteolytic enzymes. You can also understand through other people’s reviews whether a particular proteolytic enzymes fits your needs.

Assessing products online before buying the desired products from retail shops is also a very common phenomenon.

While doing the crucial research on the proteolytic enzymess available in the market, you might ask yourself a few questions that will help you reach your decision:

  • Are proteolytic enzymess worth buying?
  • What are the various pros and cons that come with purchasing proteolytic enzymes?
  • In order to buy the most efficient proteolytic enzymes at the optimum price, what are some of the things you might have to think about?
  • What are some of the proteolytic enzymes brands which are available in today’s market? What is coming in the future?
  • Is enough information on what you want accessible?
  • Why should I own a or many proteolytic enzymess, even if the quality might not be sharpest?

Other Advantages of Buying proteolytic enzymes from Online Marketplaces

Apart from some of the advantages stated before, there are certain other advantages that can be attributed to online stores:


There are a lot of promotional prices and discounts on online stores. In fact, there are more promos on online shops than there are in retail shops.  As these stores work simultaneously with multiple dealers at a time, a customer is able to avail a certain product at the best possible price.


Online marketplaces have evolved a lot since the inception of the millennium. They have become a huge source of cash flow for a lot of important people in the world.

This seismic growth of the industry is down to the reliability and trustworthiness codes that online markets follow. As a result, consumers can almost guarantee that they will get the right products at the right time and price.

Nuanced Market

There is rigidity in the items that can be sold in online shops. There is a lot of diversity and nuanced markets that help consumers find what they are looking for.

Sometimes, one might even come across something that they did not know about beforehand. The availability of alternative products is focal in ensuring the dominance of online stores.

How to Make Sure You Choose the Right proteolytic enzymes

If you are an early or new user, it might be difficult for you to find the proper proteolytic enzymes. You might be unaware of certain facets of the proteolytic enzymes that you might have been thinking about. But we are here to help you out with that! The recommendations below might be helpful in your chase:


Everyone has a budget, and they want to make purchases that fit their respective budgets. To make sure you get the best deal, surf as many markets as possible to know about the difference in prices.

This will help you get an overall idea of the status of the market. Fix your price range in accordance with your knowledge.


In the proteolytic enzymes industry, brand loyalty is very high. So consumers usually choose the brand that they have been longest associated with. Popular brands guarantee reliability.

Otherwise, the masses would not have purchased products from popular brands. Different brands have different attributes. Choose a brand whose traits you are most comfortable with.

Different brands have different visual characteristics. This also causes people to choose different products.

Customer Consensus

If you are a novice user, try consulting with active users of proteolytic enzymes. They will be able to give you practical knowledge that they have gained through usage. Sometimes you can elicit information from people that you cannot find in mainstream media – it can either be good or bad information about the product.

User reviews often become very pivotal in making people decide which brand of proteolytic enzymes they ought to buy. They might end up having the final say in the purchase decision.


It is imperative that before buying, you can understand the functionality of your proteolytic enzymes. Granted that a lot of knowledge about the product is learned through usage and experience. As there are different types, try to choose the one that parallels your requirements the most.

In The End

We can only tell you so much about buying your new best proteolytic enzymes. But we are confident that if you follow the recommendations that we have given here, you will find something that caters to your needs the best.

Best of luck with your new purchase!

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